Finding gene-environment interactions for phobias
نویسندگان
چکیده
منابع مشابه
Robustness of meta-analyses in finding gene × environment interactions
Meta-analyses that synthesize statistical evidence across studies have become important analytical tools for genetic studies. Inspired by the success of genome-wide association studies of the genetic main effect, researchers are searching for gene × environment interactions. Confounders are routinely included in the genome-wide gene × environment interaction analysis as covariates; however, thi...
متن کاملCandidate gene-environment interactions.
One of the limitations of interdisciplinarity is the misunderstanding regarding specific words and concepts from one discipline to the other ( ). One way to circumvent this aspect is to incorporate the vocabulary of other disciplines, when it corresponds to the appropriate 1 concept. Gene environment interaction is a popular topic, for which there has been to date, more reviews than established...
متن کاملUnderstanding gene-environment interactions.
doi: 10.1289/ehp.10217 In their otherwise informative and concise review of the current state of evidence concerning risk factors for acute childhood leukemia, Belson et al. (2007) did not correctly address nonionizing radiation and, in particular, power frequency magnetic fields as a possible risk factor for childhood leukemia. This failure may be due to a widespread misconception about the ev...
متن کاملXIII Gene–Environment Interactions
Most genetic-epidemiological approaches used in the study of the aetiology of individual differences in psychiatric disease in humans assume that the effects of genes and environment are additive. That is, it is assumed that the effect of an environmental risk factor does not depend on the genotype of the individual, or, stated differently, that the expression of the genotype does not depend on...
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The restricted partition method (RPM) provides a way to detect qualitative factors (e.g. genotypes, environmental exposures) associated with variation in quantitative or binary phenotypes, even if the contribution is predominantly an interaction displaying little or no signal in univariate analyses. The RPM provides a model (possibly non-linear) of the relationship between the predictor covaria...
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ژورنال
عنوان ژورنال: European Archives of Psychiatry and Clinical Neuroscience
سال: 2008
ISSN: 0940-1334,1433-8491
DOI: 10.1007/s00406-007-0786-3